From 1965 to 1972, this location was the headquarters to the "San Francisco Sound" called The Matrix. Several blues and psychedelic bands played the venue in the 60s, and Jefferson Airplane was the house band from 1965 to 1966.

According to the movie Gonzo: The Life and Work of Hunter S. Thompson, HST would frequent The Matrix and had a crush on J.A. lead singer, Grace Slick.

A memorable scene from Fear and Loathing in Las Vegas recreates a flashback from the bathroom of The Matrix with Johnny Depp and Flea of the Red Hot Chili Peppers.

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